As we age, both secreted factors and HS decrease, resulting in lower expression of anti-aging genes such as collagen and elastin, uncontrolled pigmentation and inflammation.Īn interesting fact related with HS and secreted factors is that cells cannot “see” secreted factors unless they are presented by HS (and therefore they cannot respond to them). Thus, cells are “bathing” in HS which basically orchestrated the response of these secreted factors.
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Young skin is characterized by having optimal levels of secreted factors (such as cytokines and growth factors). VV: The molecule is very critical for skin health and homeostasis (balance or equilibrated skin). Q: What effect does HS have on growth factors and cytokines, and how does this impact skin? So what happens with your endogenous HS is that cells produce different modified HS to address, for example, production of collagen and elastin, hydration, control of pigmentation or inflammation among other functions. Interestingly, the pattern of distribution of these groups, as well as their abundancy, determines which target molecule HS interacts with. This means that the core of HS is modified by the addition of sulfur groups. VV: The endogenous HS is a sulfated glycosaminoglycan or SuGAG. Q: How is SENTE’s heparan sulfate analog able to respond to what individual skin needs? This molecule can help with the appearance of lines and wrinkles, hydration (which is usually observed as flakiness and redness) and uneven pigmentation, the four main aging concerns.
Interestingly, heparan sulfate is an “intelligent molecule” that responds to the individual needs of your skin due to its multi-functionality (think about this as a magic bullet). Heparan sulfate is a key, dynamic and multi-functional molecule that plays a critical role in skin health, aging and wound healing. VV: HSA is a modified form of naturally produced heparan sulfate (HS) in which size, shape, and charge were bioengineered to be used as unique skincare technology. Q: What makes SENTE’s heparan sulfate analog (HSA) revolutionary and different from any other ingredient out there?
“Sprinkling” active ingredients is mainly driven to reduce the cost for the company but severely compromises the efficacy of the product and the credibility of the skincare industry. VV: One of the issues that we see repetitively in our industry is the addition of active ingredients into formulations at concentrations that are not sufficient to trigger effects or to support claims. Q: What are the biggest mistakes formulators make? She previously worked as the Director of Skin Biology Laboratories and Scientific Communications at SkinMedica, an Allergan Company where she was instrumental in the conceptualization and development of Retinol Complex, Total Defense + Repair, HA 5 Rejuvenating Hydrator and Lytera 2.0. I wrote her a letter of admiration, and she was incredibly kind in her reply and offered to speak with me about the science.
Virginia Vega is the Vice President of Research and Development at SENTE.
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